Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579498 | 0.99 | TSHR (0.54) | TSHRPLA2G4BDRD2 | |
| SCHEMBL9579443 | 0.84 | LTA4H (0.54) | TSHRKCNH2THRATHRB | |
| SCHEMBL7348990 | 0.84 | TP53 (0.50) | TSHRDRD2KCNH2 | |
| SCHEMBL9501962 | 0.82 | LTA4H (0.51) | TSHRKCNH2THRATHRB | |
| SCHEMBL13106499 | 0.80 | GRIN1 (0.58) | TSHRDRD2KCNH2 | |
| SCHEMBL7507055 | 0.78 | NPC1 (0.51) | TSHRDRD2 | |
| SCHEMBL10898319 | 0.78 | THRA (0.43) | TSHRPLA2G4BDRD2THRATHRB | |
| SCHEMBL7511050 | 0.77 | DHFR (0.46) | DRD2 | |
| SCHEMBL6677146 | 0.77 | TSHR (0.76) | TSHRPLA2G4BSMPD1THRATHRB | |
| SCHEMBL4208924 | 0.77 | TSHR (0.76) | TSHRPLA2G4BSMPD1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | disclosed |