Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499648 | 0.88 | NPC1 (0.59) | MAPTKMT2AMEN1NPC1HDAC1 | |
| SCHEMBL9502383 | 0.87 | HDAC1 (0.50) | MAPTTP53NPC1HDAC1KDM4E | |
| SCHEMBL7164864 | 0.87 | NPC1 (0.52) | MAPTKMT2AMEN1NPC1HDAC1 | |
| SCHEMBL9500932 | 0.87 | RAB9A (0.58) | MAPTKMT2AMEN1NPC1HDAC1 | |
| SCHEMBL8537002 | 0.86 | TRPV1 (0.58) | KMT2AMEN1NPC1HDAC1ALDH1A1 | |
| SCHEMBL9500132 | 0.86 | NPC1 (0.65) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9499536 | 0.85 | TRPV1 (0.57) | MAPTNPC1HDAC1FPR2SMN1; SMN2 | |
| SCHEMBL9500191 | 0.84 | MLYCD (0.51) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL675546 | 0.83 | KMT2A (0.42) | KMT2AMEN1HDAC1FPR2GAA | |
| SCHEMBL9499597 | 0.83 | LMNA (0.66) | MAPTKMT2AMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | claimed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | claimed |
| US-4822780-A | CALCIUM ANTAGONIST, ANTIINFLAMMATORY AGENT | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1989-04-18 | — | — | US | claimed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | claimed |
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | disclosed |