Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.80 |
| ▸ | PLK1 | P53350 | 4/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.59 |
| ▸ | RARB | P10826 | 3/20 | 0.56 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502352 | 0.91 | ACAT1 (0.77) | ACAT1PLK1NR1H4TP53TSHR | |
| SCHEMBL9503247 | 0.90 | ACAT1 (0.76) | ACAT1PLK1NR1H4TP53TSHR | |
| SCHEMBL9365137 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL9361187 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL9361036 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL9365235 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL9361027 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL6940849 | 0.89 | ACAT1 (1.00) | ACAT1PLK1NR1H4 | |
| SCHEMBL9365882 | 0.87 | ACAT1 (0.89) | ACAT1PLK1NR1H4 | |
| SCHEMBL9365182 | 0.87 | ACAT1 (0.89) | ACAT1PLK1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543884-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ATHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003408-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |