Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499401 | 0.84 | SLC6A4 (0.65) | SLC6A4HRH3SLC6A9SLC6A2 | |
| SCHEMBL29700710 | 0.83 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL679320 | 0.83 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL9501096 | 0.83 | SLC6A4 (0.64) | SLC6A4HRH3SLC6A9SLC6A2 | |
| SCHEMBL9502664 | 0.82 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A2SLC6A3NPC1 | |
| SCHEMBL7158810 | 0.82 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A9SLC6A2HTR2A | |
| Hydrochloric Acid SCHEMBL9500934 | 0.82 | SLC6A4 (0.74) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| Bromide SCHEMBL9499379 | 0.81 | SLC6A4 (0.61) | SLC6A4HRH3SLC6A9SLC6A2 | |
| SCHEMBL17278133 | 0.80 | SLC7A5 (0.70) | SLC6A4HRH3SLC6A2SLC6A3NPC1 | |
| SCHEMBL685134 | 0.79 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A9SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |