Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.63 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | PTGFR | P43088 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502807 | 0.86 | DHODH (0.64) | DHODHPOLB | |
| SCHEMBL9502835 | 0.86 | POLB (0.49) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL5498214 | 0.83 | PDE10A (0.62) | DHODHPOLB | |
| SCHEMBL8794348 | 0.80 | DHODH (0.74) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL9503660 | 0.80 | DHODH (0.78) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL14553160 | 0.78 | DHODH (0.73) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL17594286 | 0.78 | PTGFR (0.65) | DHODHPRNPPPARGRXFP1NR2E3 | |
| Hydrochloric Acid SCHEMBL28389865 | 0.77 | DHODH (0.71) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL18075840 | 0.77 | DHODH (0.78) | DHODHPRNPPPARGRXFP1NR2E3 | |
| SCHEMBL22919495 | 0.77 | LMNA (0.70) | DHODHPRNPPPARGRXFP1NR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | claimed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | claimed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | claimed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |