Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499693 | 0.96 | TDP1 (0.57) | POLBAPEX1HTTTDP1PPARD | |
| SCHEMBL9499865 | 0.96 | TDP1 (0.57) | POLBAPEX1HTTTDP1PPARD | |
| SCHEMBL713324 | 0.86 | MAPT (0.60) | POLBAPEX1HTTTDP1MAPT | |
| SCHEMBL18927175 | 0.86 | HTT (0.68) | POLBAPEX1HTTTDP1PPARD | |
| SCHEMBL9332678 | 0.85 | POLB (0.61) | POLBAPEX1HTTTDP1MAPT | |
| SCHEMBL25894065 | 0.85 | HTT (0.70) | POLBAPEX1HTTTDP1PPARD | |
| SCHEMBL18503403 | 0.85 | HTT (0.70) | POLBAPEX1HTTTDP1PPARD | |
| SCHEMBL9133114 | 0.83 | PTGS2 (0.56) | POLBAPEX1HTTTDP1MAPT | |
| SCHEMBL9119583 | 0.83 | ALDH1A1 (0.53) | HTTMAPTMEN1KMT2AGAA | |
| SCHEMBL5068525 | 0.82 | TDP1 (0.57) | POLBAPEX1HTTTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322708-B1 | POLYMERS WITH AMIDE GROUPS IN THE SIDE CHAINS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-4925589-A | ADDITION ACRYLIC TYPE POLYMER | HOFFMANN-LA ROCHE INC. (US) | 1990-05-15 | — | — | US | disclosed |
| EP-0322708-A2 | Polymers with amide groups in the side chains | F. HOFFMANN-LA ROCHE AG (CH) | 1989-07-05 | — | — | EP | disclosed |