SCHEMBL9503045

SCHEMBL9503045

COC1CCC2CC(OC(=O)c3cc(-c4ccc(C)cc4)c4c(c3N)C(=S)c3ccccc3C4=O)CCC2C1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.33
HCRTR2 O43614 2/20 0.33
SCN1A P35498 1/20 0.32
SCN2A Q99250 1/20 0.32
SCN3A Q9NY46 1/20 0.32
KDM4E B2RXH2 2/20 0.31
MAPK1 P28482 2/20 0.31
ALDH1A1 P00352 1/20 0.31
RAD52 P43351 1/20 0.31
GRK6 P43250 1/20 0.31
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
PKM P14618 1/20 0.31
KMT2A Q03164 1/20 0.31
MCL1 Q07820 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9505273 0.94 SCN1A (0.37) SCN1ASCN2ASCN3AKDM4EMAPK1
SCHEMBL9501602 0.92 ALDH1A1 (0.33) HCRTR1HCRTR2SCN1ASCN2ASCN3A
SCHEMBL9503099 0.92 SCN1A (0.32) HCRTR1HCRTR2SCN1ASCN2ASCN3A
SCHEMBL10580668 0.84 ALDH1A1 (0.33) SCN1ASCN2ASCN3AKDM4EMAPK1
SCHEMBL9503042 0.82 HTR3E (0.36) HCRTR1HCRTR2
SCHEMBL10584889 0.81 SCN1A (0.40) SCN1ASCN2ASCN3AKDM4EMAPK1
SCHEMBL9501661 0.81 MAPT (0.50) SCN1ASCN2ASCN3AKDM4EMAPK1
SCHEMBL9501671 0.81 MAPT (0.50) SCN1ASCN2ASCN3AKDM4EMAPK1
SCHEMBL9503036 0.80 ADORA2A (0.41) KDM4EMAPK1ALDH1A1GRK6MEN1
SCHEMBL9503097 0.80 P2RY4 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0307866-B1 DICHROIC COLORING AGENTS FOR LIQUID CRYSTAL DISPLAYS MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-05-12 EP disclosed
US-4883611-A ANTHRAQUINONE COMPOUND CONTAINING DECAHYDRONAPHTHYL GROUP MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1989-11-28 US disclosed
EP-0307866-A2 Dichroic coloring agents for liquid crystal displays MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-03-22 EP disclosed