Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 4/20 | 0.57 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505174 | 0.88 | MAPT (0.56) | MAPTALDH1A1TP53TSHRLMNA | |
| SCHEMBL9502523 | 0.87 | PLK1 (0.58) | MAPTPLK1ACAT1ALDH1A1NR1H4 | |
| SCHEMBL9365249 | 0.87 | ACAT1 (0.74) | MAPTPLK1ACAT1NPC1ALDH1A1 | |
| SCHEMBL9502439 | 0.86 | MAPT (0.62) | MAPTPLK1ACAT1HDAC1HDAC8 | |
| SCHEMBL9509058 | 0.85 | MAPT (0.56) | MAPTPLK1ALDH1A1TP53TSHR | |
| SCHEMBL9502352 | 0.84 | ACAT1 (0.77) | MAPTPLK1ACAT1ALDH1A1NR1H4 | |
| SCHEMBL9502442 | 0.84 | PLK1 (0.55) | MAPTPLK1ACAT1ALDH1A1NR1H4 | |
| SCHEMBL9365176 | 0.82 | ACAT1 (0.62) | MAPTPLK1ACAT1NPC1ALDH1A1 | |
| SCHEMBL9361144 | 0.82 | ACAT1 (0.68) | MAPTPLK1ACAT1NPC1ALDH1A1 | |
| SCHEMBL2839008 | 0.81 | SMN1; SMN2 (0.66) | MAPTPLK1NPC1ALDH1A1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543884-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ATHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003408-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1992-03-05 | — | — | WO | claimed |
| EP-0543884-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ATHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003408-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |