SCHEMBL9503278

SCHEMBL9503278

CSc1ccc(Oc2c(Cl)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.59
THRA P10827 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6219582 0.87 NPBWR1 (0.59) THRBTHRA
SCHEMBL9502425 0.85 THRB (0.82) THRBTHRA
SCHEMBL6213829 0.85 THRB (0.64) THRBTHRA
SCHEMBL11452514 0.84 THRB (0.55) THRBTHRA
SCHEMBL9501104 0.83 THRB (0.60) THRBTHRA
SCHEMBL24781755 0.83 THRB (0.63) THRBTHRA
SCHEMBL11465095 0.82 MEN1 (0.47) THRBTHRA
SCHEMBL9502393 0.82 THRB (0.55) THRBTHRA
SCHEMBL6214724 0.82 THRB (0.62) THRBTHRA
SCHEMBL25827400 0.81 THRB (0.66) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4198407-A Substituted 2-phenyl-1,2,4-triazine-3,5(2H,4H)-diones, and coccidiostatic agents containing same HOECHST AKTIENGESELLSCHAFT (DE) 1980-04-15 US claimed
US-5188832-A Triazine-dione compounds HOECHST AKTIENGESELLSCHAFT (DE) 1993-02-23 US disclosed
EP-0215354-B1 SUBSTITUTED 2-PHENYL-HEXAHYDRO-1,2,4-TRIAZINE-3,5-DIONES, PROCESS FOR THEIR PREPARATION, PRODUCTS CONTAINING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-04-24 EP disclosed
EP-0383285-A2 Agent against fish and insect parasites HOECHST AKTIENGESELLSCHAFT (DE) 1990-08-22 EP disclosed
US-4782056-A COCCIDIOSTATICS HOECHST AKTIENGESELLSCHAFT (DE) 1988-11-01 US disclosed
EP-0215354-A2 Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones, process for their preparation, products containing them and their use HOECHST AKTIENGESELLSCHAFT (DE) 1987-03-25 EP disclosed
US-4640917-A 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones HOECHST AKTIENGESELLSCHAFT (DE) 1987-02-03 US disclosed
US-4198407-A Substituted 2-phenyl-1,2,4-triazine-3,5(2H,4H)-diones, and coccidiostatic agents containing same HOECHST AKTIENGESELLSCHAFT (DE) 1980-04-15 US disclosed