Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13106876 | 1.00 | NR1H2 (0.48) | NR1H2NR1H3MMP2ANPEPMMP13 | |
| SCHEMBL9006094 | 0.91 | STS (0.49) | NR1H2NR1H3MMP2MMP13MMP1 | |
| SCHEMBL9503339 | 0.91 | MMP1 (0.55) | NR1H2NR1H3MMP2MMP13MMP1 | |
| SCHEMBL9507059 | 0.90 | NR1H2 (0.50) | NR1H2NR1H3MMP2MCL1CA12 | |
| SCHEMBL9506253 | 0.90 | NR1H2 (0.50) | NR1H2NR1H3MMP2MCL1CA12 | |
| SCHEMBL9505085 | 0.89 | NR1H2 (0.50) | NR1H2NR1H3MMP2ANPEPMMP13 | |
| SCHEMBL30638141 | 0.88 | MMP2 (0.52) | NR1H2NR1H3MMP2ANPEPMMP13 | |
| SCHEMBL9504084 | 0.83 | NR1H2 (0.46) | NR1H2MMP13ALDH1A1KMT2AMCL1 | |
| SCHEMBL12267639 | 0.81 | NR1H2 (0.50) | NR1H2NR1H3MMP2MCL1CA12 | |
| SCHEMBL25097911 | 0.81 | NR1H2 (0.47) | NR1H2NR1H3MMP2ANPEPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289911-B1 | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0289911-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-09 | — | — | EP | disclosed |