Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | THPO | P40225 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11806768 | 0.90 | DRD1 (0.71) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL30088530 | 0.90 | DRD1 (0.71) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL28565282 | 0.89 | DRD1 (0.67) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| Bromide SCHEMBL11805167 | 0.88 | DRD1 (0.69) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL3420775 | 0.88 | ADRB2 (0.69) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL30674028 | 0.87 | MAPT (0.67) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL5285529 | 0.87 | MAPT (0.67) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL18546398 | 0.86 | ADRB2 (0.72) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| SCHEMBL29245172 | 0.86 | ADRB2 (0.72) | MAPTHSD17B10HIF1ATSHRNFKB1 | |
| Bromide SCHEMBL9444692 | 0.85 | MAPT (0.65) | MAPTHSD17B10HIF1ATSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | claimed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | claimed |
| JP-2000743-A | — | — | None | — | — | JP | disclosed |
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5093355-A | Hypotensive agents, cardiovascular disorders, renal failure | SYNTEX (U.S.A.) INC. (US) | 1992-03-03 | — | — | US | disclosed |
| JP-H02743-A | NOVEL COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | SIMES SPA | 1990-01-05 | — | — | JP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |