Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.60 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.60 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | DRD5 | P21918 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504438 | 0.93 | ADRA1D (0.69) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9504430 | 0.92 | ADRA1D (0.68) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL10428293 | 0.79 | DRD2 (0.84) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL9503494 | 0.78 | DRD2 (0.64) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL9504487 | 0.78 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL9506540 | 0.78 | ADRA1D (0.64) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11514533 | 0.78 | DRD2 (0.82) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL467093 | 0.78 | DRD2 (1.00) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL29368857 | 0.78 | DRD2 (1.00) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9505408 | 0.77 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |