Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501966 | 0.84 | S1PR1 (0.58) | HTR2AS1PR1HTR2CSLC6A4 | |
| SCHEMBL9499669 | 0.82 | SIGMAR1 (0.41) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7510335 | 0.82 | SIGMAR1 (0.43) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7506901 | 0.80 | S1PR1 (0.50) | S1PR1 | |
| SCHEMBL9579345 | 0.76 | MGLL (0.44) | SIGMAR1DRD2S1PR1CHKA | |
| SCHEMBL9579491 | 0.75 | SIGMAR1 (0.36) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL20340801 | 0.73 | CHKA (0.53) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL3123141 | 0.73 | ADRB1 (0.50) | SIGMAR1 | |
| SCHEMBL16218815 | 0.73 | CHIA (0.55) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL16216233 | 0.73 | S1PR1 (0.47) | SIGMAR1HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | disclosed |