Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919109 | 0.84 | CYP19A1 (0.42) | CYP19A1PGRADORA3PTGS1SLC6A2 | |
| SCHEMBL10575663 | 0.83 | HPGD (0.49) | ALDH1A1CYP1A2TSHRRAB9ANPC1 | |
| SCHEMBL3914952 | 0.82 | CYP19A1 (0.40) | CYP19A1PGRADORA3PTGS1SLC6A2 | |
| SCHEMBL356002 | 0.81 | HSD17B10 (0.56) | CYP19A1ALDH1A1CYP1A2TSHRRAB9A | |
| SCHEMBL30858931 | 0.80 | LMNA (0.56) | ALDH1A1CYP1A2TSHRRAB9ANPC1 | |
| SCHEMBL134991 | 0.80 | LMNA (0.56) | ALDH1A1CYP1A2TSHRRAB9ANPC1 | |
| Water SCHEMBL8818123 | 0.79 | HSD17B10 (0.55) | CYP19A1ALDH1A1CYP1A2TSHRRAB9A | |
| SCHEMBL355182 | 0.78 | TSHR (0.57) | PGRADORA3PTGS1SLC6A2ALDH1A1 | |
| SCHEMBL3916987 | 0.78 | KMT2A (0.45) | ALDH1A1CYP1A2TSHRRAB9ANPC1 | |
| SCHEMBL10573667 | 0.78 | HSD17B10 (0.47) | ALDH1A1CYP1A2TSHRRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336561-B1 | 2-PYRIDYLACETIC ACID DERIVATIVES, PREPARATIONS THEREOF, AND COMPOSITIONS CONTAINING THEM | SUNTORY LIMITED (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| EP-0336561-A1 | 2-Pyridylacetic acid derivatives, preparations thereof, and compositions containing them | SUNTORY LIMITED (JP) | 1989-10-11 | — | — | EP | disclosed |
| US-4843083-A | 2-pyridylacetic acid derivative, and pharmaceutical composition containing the same and method of treating a peptic ulcer | SUNTORY LIMITED (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | disclosed |