Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12326581 | 0.86 | HTR6 (0.67) | KDM4EGAAMEN1TUBB4ATUBB | |
| SCHEMBL7380594 | 0.82 | KDM4E (0.60) | KDM4EGAAEGFRMEN1TUBB4A | |
| SCHEMBL2012674 | 0.82 | KDM4E (0.61) | KDM4EEGFRSRCMEN1KMT2A | |
| SCHEMBL7838039 | 0.82 | ALOX15 (0.47) | NR4A2 | |
| SCHEMBL16497460 | 0.80 | MAP2K1 (0.46) | KDM4EGAAKMT2AALDH1A1HSD17B10 | |
| SCHEMBL5955783 | 0.80 | HTR6 (0.58) | KDM4EGAAEGFRSRCMEN1 | |
| SCHEMBL3276728 | 0.80 | EGFR (0.66) | KDM4EGAAEGFRSRCMEN1 | |
| SCHEMBL9501275 | 0.79 | HTR6 (0.57) | KDM4EGAAEGFRMEN1TUBB4A | |
| SCHEMBL28402205 | 0.79 | EGFR (0.52) | KDM4EGAAEGFRSRCMEN1 | |
| SCHEMBL9499798 | 0.79 | HTR6 (0.76) | KDM4EGAAEGFRSRCMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233413-B1 | 3-(2-AMINOETHYL)INDOLE AND -INDOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-05-05 | — | — | EP | disclosed |
| US-4980368-A | CEREBRALVASCULAR DISORDERS; ANTIHYPOXIA AGENTS; COGNITION ACTIVATORS; SENILITY | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1990-12-25 | — | — | US | disclosed |
| EP-0233413-A2 | 3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1987-08-26 | — | — | EP | disclosed |