Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929104 | 0.80 | KMT2A (0.37) | ALDH1A1POLBTSHR | |
| SCHEMBL1929102 | 0.80 | KMT2A (0.37) | ALDH1A1POLBTSHR | |
| SCHEMBL22013347 | 0.80 | LTA4H (0.30) | LTA4H | |
| SCHEMBL875722 | 0.78 | LTA4H (0.38) | LTA4HPTGS2TSHRSOAT1 | |
| SCHEMBL9296437 | 0.78 | ALDH1A1 (0.35) | PTGS2ALDH1A1POLB | |
| SCHEMBL7529688 | 0.77 | LTA4H (0.37) | LTA4HPTGS2MAPTTSHRSOAT1 | |
| SCHEMBL2655578 | 0.77 | LTA4H (0.37) | LTA4HPTGS2TSHRSOAT1 | |
| SCHEMBL706147 | 0.77 | TSHR (0.32) | ALDH1A1TSHR | |
| SCHEMBL703534 | 0.77 | TSHR (0.32) | ALDH1A1TSHR | |
| SCHEMBL3481751 | 0.75 | LTA4H (0.36) | LTA4HPTGS2ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550566-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS (US) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005153-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS, INC. (US) | 1992-04-02 | — | — | WO | disclosed |