Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875722 | 0.98 | LTA4H (0.38) | LTA4HPTGS2TSHRCETPSOAT1 | |
| SCHEMBL9334179 | 0.85 | DRD2 (0.34) | LTA4HPTGS2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2655578 | 0.84 | LTA4H (0.37) | LTA4HPTGS2TSHRSOAT1PCSK9 | |
| SCHEMBL18328936 | 0.83 | SOAT1 (0.32) | LTA4HPTGS2SOAT1 | |
| SCHEMBL7408504 | 0.82 | LTA4H (0.36) | LTA4HPTGS2TSHRSOAT1PCSK9 | |
| SCHEMBL2655575 | 0.82 | LTA4H (0.36) | LTA4HPTGS2TSHRSOAT1PCSK9 | |
| SCHEMBL3481751 | 0.82 | LTA4H (0.36) | LTA4HPTGS2TSHRSOAT1PCSK9 | |
| SCHEMBL3481385 | 0.81 | LTA4H (0.39) | LTA4HPTGS2TSHRSOAT1CYP1A2 | |
| SCHEMBL28174657 | 0.79 | LTA4H (0.34) | LTA4HPTGS2TSHRSOAT1PCSK9 | |
| SCHEMBL28039482 | 0.79 | PTGS2 (0.37) | LTA4HPTGS2TSHRSOAT1PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185539-A1 | ORGANOSILYL COMPOUNDS HAVING NUCLEAR HORMONE RECEPTOR MODULATING ACTIVITY | Allergan Sales, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-1185277-A1 | METHODS FOR MODULATING FXR RECEPTOR ACTIVITY | Allergan Sales, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076523-A1 | METHODS FOR MODULATING FXR RECEPTOR ACTIVITY | ALLERGAN SALES, INC. (US) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000077011-A1 | ORGANOSILYL COMPOUNDS HAVING NUCLEAR HORMONE RECEPTOR MODULATING ACTIVITY | ALLERGAN SALES, INC. (US) | 2000-12-21 | — | — | WO | disclosed |