SCHEMBL950464

SCHEMBL950464

Cc1ccc2c(=O)oc(-c3cc(C(F)(F)F)nn3-c3ncccc3Cl)nc2c1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ C1R P00736 5/20 0.42
▸ ALDH1A1 P00352 4/20 0.37
▸ MAPT P10636 4/20 0.37
▸ POLB P06746 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ F7 P08709 1/20 0.37
▸ F3 P13726 1/20 0.37
▸ KDM4E B2RXH2 4/20 0.36
▸ LMNA P02545 1/20 0.36
▸ ELANE P08246 2/20 0.36
▸ PBRM1 Q86U86 1/20 0.35
▸ APEX1 P27695 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ NR3C2 P08235 1/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ TRPV1 Q8NER1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950741 0.93 ELANE (0.45) C1RALDH1A1MAPTPOLBKDM4E
SCHEMBL949711 0.91 APEX1 (0.45) C1RALDH1A1MAPTPOLBNPSR1
SCHEMBL13072420 0.89 ELANE (0.39) C1RALDH1A1MAPTPOLBNPSR1
SCHEMBL12911905 0.85 KDM4E (0.35) ALDH1A1MAPTKDM4EELANEL3MBTL1
SCHEMBL536107 0.85 OPRL1 (0.34) C1RALDH1A1MAPTPOLBNPSR1
SCHEMBL950869 0.85 C1R (0.43) C1RALDH1A1MAPTPOLBNPSR1
SCHEMBL950884 0.85 KDM4E (0.34) ALDH1A1MAPTKDM4EELANEL3MBTL1
SCHEMBL535653 0.84 F2 (0.44) C1RALDH1A1MAPTF7F3
SCHEMBL950940 0.84 ELANE (0.45) ALDH1A1MAPTKDM4EELANEL3MBTL1
SCHEMBL950449 0.84 ELANE (0.48) C1RELANEPBRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 — — EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 — — WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 C1R 1132/4885ALDH1A1 238/4885MAPT 4535/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT C1R 4485/4885ALDH1A1 436/4885MAPT 3656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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