Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504721 | 0.90 | THRA (0.63) | ALOX5THRATHRB | |
| SCHEMBL9504766 | 0.89 | THRA (0.58) | THRATHRB | |
| SCHEMBL9504831 | 0.88 | ALOX5 (0.51) | ALOX5THRATHRBHDAC1HDAC6 | |
| SCHEMBL9508914 | 0.84 | THRA (0.56) | ALOX5THRATHRB | |
| SCHEMBL28592135 | 0.84 | HPGD (0.50) | ALOX5HDAC1HDAC6 | |
| SCHEMBL9504560 | 0.83 | THRA (0.58) | THRATHRB | |
| SCHEMBL9508859 | 0.83 | THRA (0.61) | THRATHRB | |
| SCHEMBL9504798 | 0.83 | THRA (0.58) | THRATHRB | |
| SCHEMBL9504692 | 0.83 | THRA (0.58) | THRATHRB | |
| SCHEMBL9504638 | 0.83 | ALOX5 (0.64) | ALOX5HDAC1HDAC6RCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |