Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.44 |
| ▸ | MMP3 | P08254 | 8/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506871 | 0.89 | KEAP1 (0.45) | MMP1MMP3MMP9MMP2 | |
| SCHEMBL7212144 | 0.88 | MMP1 (0.51) | MMP1MMP3MMP2 | |
| SCHEMBL9506273 | 0.87 | MMP3 (0.46) | MMP1MMP3MMP2 | |
| SCHEMBL9506268 | 0.87 | MMP3 (0.46) | MMP1MMP3MMP2 | |
| SCHEMBL9503909 | 0.85 | MMP3 (0.45) | MMP1MMP3MMP9MMP2 | |
| SCHEMBL9503917 | 0.85 | MMP3 (0.45) | MMP1MMP3MMP9MMP2 | |
| SCHEMBL10594004 | 0.84 | MMP1 (0.40) | MMP1MMP3MMP9MMP2 | |
| SCHEMBL9506880 | 0.84 | MMP1 (0.42) | MMP1MMP3MMP2 | |
| SCHEMBL9503868 | 0.84 | MEN1 (0.43) | MMP1MMP3MMP2 | |
| SCHEMBL9506173 | 0.84 | MMP1 (0.50) | MMP1MMP3MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-5006651-A | Rheumatic diseases, bone disorders | HOFFMAN-LA ROCHE INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0276436-A1 | Phosphinic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-08-03 | — | — | EP | disclosed |