SCHEMBL950522

SCHEMBL950522

Clc1cccnc1-n1ccc(I)n1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RPS6KA5 O75582 4/20 0.34
MET P08581 2/20 0.34
RPS6KA4 O75676 1/20 0.34
HSD11B1 P28845 1/20 0.34
ADORA2A P29274 1/20 0.33
TRPA1 O75762 2/20 0.33
MALT1 Q9UDY8 1/20 0.33
HDAC8 Q9BY41 1/20 0.32
KCNH2 Q12809 1/20 0.32
TRPM8 Q7Z2W7 1/20 0.32
TRPV1 Q8NER1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023418 0.83 ADORA2A (0.41) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL639253 0.82 HSD11B1 (0.35) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL27793748 0.79 RPS6KA5 (0.35) RPS6KA5HSD11B1ADORA2ATRPA1MALT1
SCHEMBL29859811 0.79 KDM4E (0.39) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL435321 0.79 RPS6KA5 (0.35) RPS6KA5HSD11B1ADORA2ATRPA1MALT1
SCHEMBL23248718 0.78 RPS6KA5 (0.35) RPS6KA5HSD11B1ADORA2ATRPA1MALT1
Magnesium SCHEMBL29535504 0.78 RPS6KA5 (0.35) RPS6KA5HSD11B1ADORA2ATRPA1MALT1
SCHEMBL31059968 0.78 NPC1 (0.48) HSD11B1MALT1TRPV1
SCHEMBL13484047 0.76 ADORA2A (0.37) RPS6KA5ADORA2ATRPA1
SCHEMBL12559310 0.76 OPRM1 (0.34) RPS6KA5HSD11B1ADORA2ATRPA1MALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 RPS6KA5 2425/4885MET 4243/4885RPS6KA4 1990/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT RPS6KA5 3415/4885MET 3781/4885RPS6KA4 3279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.