Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CD69 | Q07108 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16005822 | 0.87 | KMT2A (0.56) | KMT2APTPN7PTPN12PTPN22ALDH1A1 | |
| SCHEMBL7172967 | 0.85 | KMT2A (0.74) | KMT2APTPN7PTPN12PTPN22ALDH1A1 | |
| SCHEMBL3729436 | 0.83 | KMT2A (1.00) | KMT2APTPN7PTPN12PTPN22ALDH1A1 | |
| SCHEMBL22307856 | 0.82 | KMT2A (0.69) | KMT2APTPN7PTPN12PTPN22ALDH1A1 | |
| SCHEMBL7892180 | 0.79 | ALDH1A1 (0.47) | KMT2AALDH1A1POLBGAAMAPT | |
| SCHEMBL4362921 | 0.79 | KMT2A (0.46) | KMT2AALDH1A1POLBCD69RAB9A | |
| SCHEMBL9722695 | 0.79 | MRGPRX4 (0.51) | KMT2AALDH1A1POLBGAAMAPT | |
| SCHEMBL5109846 | 0.79 | KMT2A (0.65) | KMT2APTPN7PTPN12PTPN22ALDH1A1 | |
| SCHEMBL2058983 | 0.78 | KMT2A (0.54) | KMT2AALDH1A1POLBMAPTRAB9A | |
| SCHEMBL9722723 | 0.78 | KMT2A (0.44) | KMT2AALDH1A1CD69RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5139564-A | Applying postemergence | PARK SANG W (KR) | 1992-08-18 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0195201-B1 | PROCESS FOR THE PREPARATION OF N-ACYL-2,3-DEHYDRO CARBOXYLIC ESTERS | Degussa Aktiengesellschaft (DE) | 1990-05-23 | — | — | EP | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |
| EP-0195201-A2 | Process for the preparation of N-acyl-2,3-dehydro carboxylic esters | Degussa Aktiengesellschaft (DE) | 1986-09-24 | — | — | EP | disclosed |