Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 7/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10418957 | 0.88 | CASP1 (0.49) | CASP1FFAR1KMT2AHPGDALDH1A1 | |
| SCHEMBL9507749 | 0.87 | CASP1 (0.51) | CASP1KMT2AGLA | |
| SCHEMBL14328819 | 0.82 | ALDH1A1 (0.51) | CASP1EPHX2NR1H4KMT2AHPGD | |
| SCHEMBL3419896 | 0.82 | CASP1 (0.50) | CASP1FFAR1KMT2AALDH1A1MEN1 | |
| SCHEMBL7624194 | 0.81 | CASP1 (0.68) | CASP1ALDH1A1MAPT | |
| SCHEMBL991422 | 0.81 | CASP1 (0.55) | CASP1EPHX2NR1H4FFAR1ALDH1A1 | |
| SCHEMBL9508841 | 0.81 | CASP1 (0.52) | CASP1KMT2AALOX15ALDH1A1MEN1 | |
| SCHEMBL8870036 | 0.80 | CSNK2A2 (0.54) | CASP1EPHX2NR1H4FFAR1KMT2A | |
| SCHEMBL992370 | 0.80 | CASP1 (0.53) | CASP1KMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL991807 | 0.80 | CASP1 (0.53) | CASP1EPHX2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278911-B1 | BICYCLIC BETA-LACTAM CARBOXYLIC ACIDS | CIBA-GEIGY AG (CH) | 1993-08-04 | — | — | EP | disclosed |
| US-4965260-A | PENICILLINS | CIBA-GEIGY CORPORATION (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0278911-A1 | Bicyclic beta-lactam carboxylic acids | CIBA-GEIGY AG (CH) | 1988-08-17 | — | — | EP | disclosed |