SCHEMBL9505610

SCHEMBL9505610

NNC(=O)N(c1ccccc1)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.40
CTSD P07339 1/20 0.38
CES1 P23141 2/20 0.38
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
ALDH1A1 P00352 3/20 0.36
MLYCD O95822 2/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
P2RX7 Q99572 1/20 0.35
MAOB P27338 1/20 0.35
NR1H3 Q13133 1/20 0.35
POLQ O75417 1/20 0.35
NPC1 O15118 1/20 0.34
POLB P06746 1/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28294173 0.85 NPSR1 (0.38) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL5476751 0.85 LMNA (0.39) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL27728396 0.83 MEN1 (0.51) NPSR1KMT2AMEN1ALDH1A1MLYCD
SCHEMBL1067570 0.82 NPSR1 (0.41) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL1008397 0.81 NPSR1 (0.44) NPSR1CES1KMT2AMEN1ALDH1A1
Carbamic Acid SCHEMBL1013200 0.80 NPSR1 (0.40) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL3938034 0.79 NPSR1 (0.43) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL7747329 0.78 MTNR1A (0.37) KMT2AMEN1ALDH1A1MLYCDCYP3A4
SCHEMBL7827701 0.78 NPSR1 (0.41) NPSR1CES1KMT2AMEN1ALDH1A1
SCHEMBL28247945 0.78 NPSR1 (0.41) NPSR1CES1KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0553284-A1 SEMICARBAZONE ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-08-04 EP disclosed