SCHEMBL9506407

SCHEMBL9506407

COC1=CC(=O)N(c2cccc(Cl)c2)C1=O

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
ALDH1A1 P00352 5/20 0.56
MAPT P10636 3/20 0.56
MAPK1 P28482 1/20 0.56
MGLL Q99685 2/20 0.53
GAA P10253 3/20 0.43
PGR P06401 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
KDM4E B2RXH2 1/20 0.42
TSHR P16473 1/20 0.42
HTT P42858 1/20 0.42
BCL2A1 Q16548 1/20 0.42
CASP6 P55212 1/20 0.41
GRM5 P41594 1/20 0.40
MPO P05164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508528 0.79 MGLL (0.58) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1471712 0.77 MAPT (0.62) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL10834455 0.76 MGLL (0.58) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1471837 0.76 MAPT (0.51) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL3817547 0.74 ALDH1A1 (0.47) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1473800 0.73 MEN1 (0.46) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL17221860 0.72 HSP90AA1 (0.32) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL934144 0.72 MGLL (0.53) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1471117 0.72 MGLL (0.53) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1471051 0.72 MAPT (0.49) MEN1KMT2AALDH1A1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0267574-B1 HEAT RESISTANT COPOLYMER COMPOSITION Sumitomo Dow Limited (JP) 1993-09-01 EP disclosed
US-4877833-A BLEND OF POLYMERS OF SPECIFIC COMPOSITION SUMITOMO NAUGATUCK CO., LTD. (JP) 1989-10-31 US disclosed
EP-0031997-B2 POLYMERISATION PROCESS FOR PRODUCTION OF POLYMER MICROPARTICLES OF HIGH REFRACTIVE INDEX AND COATING COMPOSITIONS CONTAINING THEM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-09-14 EP disclosed
US-4427820-A STYRENE, MALEIC ACID DERIVATIVE, EMULSION POLYMERIZATION IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-24 US disclosed
EP-0031997-B1 POLYMERISATION PROCESS FOR PRODUCTION OF POLYMER MICROPARTICLES OF HIGH REFRACTIVE INDEX AND COATING COMPOSITIONS CONTAINING THEM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-12-28 EP disclosed
EP-0031997-A1 Polymerisation process for production of polymer microparticles of high refractive index and coating compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-07-15 EP disclosed