Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671409 | 0.99 | BID (0.46) | ALOX5POLBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL9504375 | 0.84 | ALOX5 (0.58) | ALOX5POLBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL9504787 | 0.81 | ALOX5 (0.50) | ALOX5POLBKMT2A | |
| SCHEMBL11710027 | 0.76 | FOLH1 (0.61) | POLBSMN1; SMN2HPGDALDH1A1ADRB2 | |
| SCHEMBL3280275 | 0.76 | TP53 (0.45) | POLBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11843011 | 0.74 | ALDH1A1 (0.47) | ALOX5SMN1; SMN2HPGDALDH1A1ADRB2 | |
| SCHEMBL29410986 | 0.73 | BID (0.51) | POLBSMN1; SMN2HPGDALDH1A1ADRB2 | |
| SCHEMBL17554515 | 0.73 | BID (0.46) | SMN1; SMN2HPGDALDH1A1ADRB2HTT | |
| SCHEMBL20162476 | 0.73 | FOLH1 (0.61) | SMN1; SMN2ALDH1A1ADRB2BIDBCL2L1 | |
| SCHEMBL10641307 | 0.72 | SLC16A3 (0.52) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |