SCHEMBL950774

SCHEMBL950774

Cc1cc(Cl)cc2c1[N+]([O-])=C(c1cc(C(F)(F)F)nn1-c1ccccn1)OC2

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ NR3C2 P08235 5/20 0.35
▸ NR3C1 P04150 3/20 0.35
▸ PGR P06401 3/20 0.35
▸ PTGS2 P35354 4/20 0.34
▸ PTGS1 P23219 3/20 0.34
▸ CACNA1B Q00975 1/20 0.33
▸ AR P10275 1/20 0.33
▸ TGFBR1 P36897 1/20 0.33
▸ MEN1 O00255 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL951266 0.87 PTGS1 (0.44) NR3C2NR3C1PGRPTGS2PTGS1
SCHEMBL950412 0.80 OPRL1 (0.35) NR3C2NR3C1PGRPTGS2PTGS1
SCHEMBL951273 0.80 NR3C1 (0.31) NR3C2NR3C1PGRAR
SCHEMBL951137 0.79 GRIN1 (0.33) —
SCHEMBL990884 0.79 NR3C1 (0.31) NR3C2NR3C1PGRAR
SCHEMBL951280 0.79 STIM1 (0.32) NR3C2NR3C1PGRAR
SCHEMBL954789 0.79 KDM4E (0.35) NR3C2PTGS2PTGS1MEN1MAPT
SCHEMBL950738 0.77 PTGS2 (0.33) NR3C2PTGS2PTGS1MEN1MAPT
SCHEMBL951523 0.76 NR3C2 (0.36) NR3C2
SCHEMBL952307 0.73 OPRL1 (0.34) NR3C2NR3C1PGRPTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 — — EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 NR3C2 3510/4885NR3C1 4164/4885PGR 4133/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT NR3C2 3760/4885NR3C1 4348/4885PGR 4613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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