Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 17/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508016 | 0.89 | TYMS (0.58) | TYMS | |
| SCHEMBL9080093 | 0.76 | TYMS (1.00) | TYMS | |
| SCHEMBL9504568 | 0.75 | TYMS (0.69) | TYMS | |
| SCHEMBL9508662 | 0.72 | TYMS (0.59) | TYMS | |
| SCHEMBL9506760 | 0.67 | TYMS (0.58) | TYMS | |
| Metesind SCHEMBL6703943 | 0.66 | TYMS (1.00) | TYMS | |
| SCHEMBL9504724 | 0.66 | TYMS (0.52) | TYMS | |
| SCHEMBL9055601 | 0.66 | TYMS (1.00) | TYMSHDAC3HDAC1HDAC11HDAC8 | |
| SCHEMBL9702076 | 0.65 | TYMS (0.75) | TYMS | |
| SCHEMBL9080571 | 0.65 | TYMS (0.79) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550566-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS (US) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005153-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS, INC. (US) | 1992-04-02 | — | — | WO | disclosed |