Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30936706 | 0.72 | MAPT (0.59) | KMT2AMEN1MAPTCRHBPCRHR2 | |
| SCHEMBL9588187 | 0.72 | CRHBP (0.46) | TYMSKMT2AMEN1MAPTCRHBP | |
| SCHEMBL9508011 | 0.72 | TYMS (0.73) | TYMS | |
| SCHEMBL9055262 | 0.71 | TYMS (0.47) | TYMSMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL9586568 | 0.70 | KMT2A (0.44) | KMT2AMEN1MAPTCRHBPCRHR2 | |
| SCHEMBL12083406 | 0.69 | ALDH1A1 (0.59) | TYMSMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8016610 | 0.69 | CYP19A1 (0.50) | KMT2AMEN1RAB9AALDH1A1POLB | |
| SCHEMBL9508035 | 0.68 | TYMS (0.55) | TYMSCRHBPCRHR2RAB9A | |
| SCHEMBL19700164 | 0.68 | MAPT (0.51) | KMT2AMEN1MAPTCRHBPCRHR2 | |
| SCHEMBL5281106 | 0.67 | MAPT (0.62) | KMT2AMEN1MAPTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550566-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS (US) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005153-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS, INC. (US) | 1992-04-02 | — | — | WO | disclosed |