Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508490 | 0.80 | MEN1 (0.33) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL9509316 | 0.72 | DAO (0.42) | — | |
| SCHEMBL7198771 | 0.70 | MTNR1A (0.43) | — | |
| SCHEMBL3881019 | 0.68 | MEN1 (0.42) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL9142939 | 0.66 | ALDH1A1 (0.47) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL9508484 | 0.64 | MEN1 (0.36) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL9565814 | 0.60 | ALDH1A1 (0.40) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL12156616 | 0.60 | ALDH1A1 (0.50) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL13453317 | 0.60 | ALDH1A1 (0.50) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL255965 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |