Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.31 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HTR2B | P41595 | 3/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508478 | 0.80 | MEN1 (0.33) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL9722865 | 0.73 | SIGMAR1 (0.42) | HTR2AHTR2CRETHRH1 | |
| SCHEMBL7900045 | 0.72 | HTR2A (0.38) | HTR2AHTR2CRETHRH1 | |
| SCHEMBL9509328 | 0.72 | DAO (0.42) | — | |
| SCHEMBL7198771 | 0.70 | MTNR1A (0.43) | — | |
| SCHEMBL3881019 | 0.68 | MEN1 (0.42) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL8437084 | 0.68 | HTR2A (0.42) | MEN1KMT2AALDH1A1HTR2AHTR2C | |
| SCHEMBL9142939 | 0.66 | ALDH1A1 (0.47) | MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL6421835 | 0.64 | MEN1 (0.51) | MEN1NPC1KMT2AALDH1A1HTR2A | |
| SCHEMBL9508484 | 0.64 | MEN1 (0.36) | MEN1NPC1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |