SCHEMBL9509015

SCHEMBL9509015

CCOc1ccc(C#Cc2ccc([C@H]3CC[C@H](CC)CC3)cc2)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACACB O00763 4/20 0.38
KDM1A O60341 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9512338 0.92 ACACB (0.34) ACACB
SCHEMBL9512340 0.91 RAB9A (0.35) ACACB
SCHEMBL7908845 0.91 CYP2C9 (0.41) ACACBKDM1A
SCHEMBL21165797 0.91 CYP2C9 (0.41) ACACBKDM1A
SCHEMBL23618045 0.91 ACACB (0.33) ACACB
SCHEMBL9512315 0.91 ACACB (0.33) ACACB
SCHEMBL9509319 0.90 ACACB (0.33) ACACB
SCHEMBL21165799 0.89 ESR2 (0.37) ACACBKDM1A
SCHEMBL9511367 0.89 ESR2 (0.37) ACACBKDM1A
SCHEMBL9510166 0.89 CYP2C9 (0.34) ACACBKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP claimed
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed