Sugi Predict

Sugi Predict / Compounds / SCHEMBL950947

SCHEMBL950947

SCHEMBL950947

CCn1nc(C(F)(F)F)cc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GRN P28799 7/20 0.49
▸ SORT1 Q99523 7/20 0.49
▸ KLKB1 P03952 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ KDM4E B2RXH2 2/20 0.44
▸ NPC1 O15118 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ TP53 P04637 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ MAPT P10636 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ STIM1 Q13586 1/20 0.38
▸ ORAI1 Q96D31 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10447771 0.87 GRN (0.51) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL28013854 0.85 LMNA (0.45) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL2311794 0.85 GRN (0.66) GRNSORT1KDM4ENPC1ALDH1A1
SCHEMBL28943994 0.84 CNR1 (0.50) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL27699443 0.82 CNR1 (0.54) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL28123454 0.81 CNR1 (0.47) LMNAKDM4EPOLBTSHRTP53
SCHEMBL18893849 0.81 KLKB1 (0.44) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL22637837 0.80 GRN (0.51) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL22637870 0.80 TP53 (0.50) GRNSORT1KLKB1LMNAKDM4E
SCHEMBL22637048 0.80 KDM4E (0.56) GRNSORT1KLKB1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104592116-B 1,3,5-trisubstituted pyrazole compounds, and preparation method and application thereof 山东大学 2017-01-11 — — CN claimed
CN-104592116-A 1,3,5-trisubstituted pyrazole compounds, and preparation method and application thereof UNIV SHANDONG 2015-05-06 — — CN claimed
US-20250108048-A1 STING AGONIST COMPOUNDS AND CONJUGATES SUTRO BIOPHARMA, INC. 2025-04-03 — — US disclosed
WO-2025029832-A2 STING AGONIST COMPOUNDS AND CONJUGATES SUTRO BIOPHARMA, INC. (US) 2025-02-06 — — WO disclosed
US-20240383903-A1 Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2024-11-21 — — US disclosed
US-11964978-B2 Modulators of STING (stimulator of interferon genes) PFIZER INC. (US) 2024-04-23 — — US disclosed
EP-4308563-A1 MODULATORS OF STING (STIMULATOR OF INTERFERON GENES) Pfizer Inc. (US) 2024-01-24 — — EP disclosed
CN-117321055-A Modulators of STING (interferon gene stimulators) 辉瑞公司 2023-12-29 — — CN disclosed
US-20220306641-A1 Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2022-09-29 — — US disclosed
WO-2022195462-A1 MODULATORS OF STING (STIMULATOR OF INTERFERON GENES) PFIZER INC. (US) 2022-09-22 — — WO disclosed
WO-2020132566-A1 STING PYRAZOLE AGONISTS AND USES THEREOF NIMBUS TITAN, INC. (US) 2020-06-25 — — WO disclosed
EP-1700845-A1 Insecticidal anthranilamides E.I.Du pont de nemours and company (US) 2006-09-13 — — EP disclosed
US-20060079561-A1 Insecticidal anthranilamides FMC CORPORATION 2006-04-13 — — US disclosed
US-6995178-B2 Insecticidal anthranilamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-02-07 — — US disclosed
CN-1713819-A Anthranilamide arthropodicide treatment DU PONT (US) 2005-12-28 — — CN disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 — — US disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 — — US disclosed
US-20040142984-A1 Insecticidal anthranilamides FMC CORPORATION 2004-07-22 — — US disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 — — US disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250108048-A1 STING AGONIST COMPOUNDS AND CONJUGATES STING1, CGAS, MAVS GRN 3398/4885SORT1 4135/4885KLKB1 944/4885
US-20040142984-A1 Insecticidal anthranilamides ANTXR2, NIT2, AKR7A2 GRN 4628/4885SORT1 4688/4885KLKB1 3650/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 GRN 2638/4885SORT1 1794/4885KLKB1 4175/4885
US-20060079561-A1 Insecticidal anthranilamides ANTXR2, CYB5R3, NIT2 GRN 4582/4885SORT1 4568/4885KLKB1 3173/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 GRN 4664/4885SORT1 4741/4885KLKB1 3480/4885
US-11964978-B2 Modulators of STING (stimulator of interferon genes) STING1, IRF3, CGAS GRN 975/4885SORT1 4812/4885KLKB1 2569/4885
US-20220306641-A1 Modulators of STING (Stimulator of Interferon Genes) STING1, IRF3, CGAS GRN 975/4885SORT1 4812/4885KLKB1 2569/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 GRN 3403/4885SORT1 3118/4885KLKB1 3842/4885
US-20240383903-A1 Modulators of STING (Stimulator of Interferon Genes) STING1, IRF3, CGAS GRN 975/4885SORT1 4812/4885KLKB1 2569/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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