Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10411798 | 0.89 | MTNR1A (0.47) | PLA2G4B | |
| SCHEMBL9510354 | 0.88 | PLA2G4B (0.55) | PLA2G4B | |
| SCHEMBL10411015 | 0.87 | MTNR1A (0.47) | KMT2ANR1H4 | |
| SCHEMBL9325227 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL9323942 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL9324552 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL9325513 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL9326084 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL9325773 | 0.87 | PLA2G2A (0.65) | PLA2G4B | |
| SCHEMBL10411797 | 0.87 | CYSLTR1 (0.49) | PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | disclosed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | disclosed |