Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 4/20 | 0.46 |
| ▸ | MCOLN1 | Q9GZU1 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251628 | 0.85 | SIGMAR1 (0.45) | MCOLN2MCOLN1DRD2DRD3CRHBP | |
| 1,2-Dichlorobenzene SCHEMBL9641798 | 0.85 | SIGMAR1 (0.46) | SLC18A3 | |
| SCHEMBL9258031 | 0.84 | OPRK1 (0.62) | ALDH1A1TSHRSMN1; SMN2 | |
| 1,2-Dichlorobenzene SCHEMBL9643933 | 0.83 | SIGMAR1 (0.54) | TSHR | |
| 1,2-Dichlorobenzene SCHEMBL9643364 | 0.82 | SIGMAR1 (0.53) | — | |
| SCHEMBL9251634 | 0.82 | MCOLN2 (0.46) | MCOLN2MCOLN1DRD2DRD3CRHBP | |
| SCHEMBL11603608 | 0.74 | SLC18A3 (0.64) | MCOLN2MCOLN1DRD2DRD3SLC18A3 | |
| SCHEMBL11603611 | 0.74 | SLC18A3 (0.64) | MCOLN2MCOLN1DRD2DRD3SLC18A3 | |
| SCHEMBL11603615 | 0.74 | SLC18A3 (0.64) | MCOLN2MCOLN1DRD2DRD3SLC18A3 | |
| 1,2-Dimethoxybenzene SCHEMBL10589067 | 0.74 | SIGMAR1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374054-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-10-06 | — | — | EP | disclosed |