Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189864 | 1.00 | PTGS1 (0.47) | PTGS1CA1CA2CES2CES1 | |
| SCHEMBL9510836 | 1.00 | PTGS1 (0.47) | PTGS1CA1CA2CES2CES1 | |
| SCHEMBL30450782 | 0.80 | ALDH1A1 (0.46) | CES2CES1HPGDMAPTMEN1 | |
| SCHEMBL11649733 | 0.80 | ALDH1A1 (0.46) | CES2CES1HPGDMAPTMEN1 | |
| SCHEMBL7911566 | 0.80 | ESR1 (0.54) | PTGS1CA1CA2TSHRALOX15 | |
| SCHEMBL9609532 | 0.80 | ALDH1A1 (0.46) | CES2CES1HPGDMAPTMEN1 | |
| SCHEMBL28535936 | 0.79 | TYR (0.47) | HPGDMAPTMEN1HTTRAB9A | |
| SCHEMBL11263134 | 0.79 | TYR (0.47) | HPGDMAPTMEN1HTTRAB9A | |
| SCHEMBL24554809 | 0.78 | CA1 (0.46) | PTGS1CA1CA2CES2CES1 | |
| SCHEMBL9609552 | 0.78 | CA1 (0.46) | CA1CA2CES2CES1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753384-B2 | Production method for 5,5-di-substituted-4,5-dihydroisoxazole | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2023-09-12 | — | — | US | disclosed |
| EP-3789382-B1 | PRODUCTION METHOD FOR 5,5-DI-SUBSTITUTED-4,5-DIHYDROISOXAZOLE | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2023-07-05 | — | — | EP | disclosed |
| CN-111491926-B | Novel method for producing 5, 5-disubstituted-4, 5-dihydroisoxazole | 组合化学工业株式会社 | 2022-07-15 | — | — | CN | disclosed |
| EP-3725782-B1 | NOVEL METHOD FOR PRODUCING 5,5-DISUBSTITUTED-4,5-DIHYDROISOXAZOLE | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2022-06-22 | — | — | EP | disclosed |
| US-20210238150-A1 | PRODUCTION METHOD FOR 5,5-DI-SUBSTITUTED-4,5-DIHYDROISOXAZOLE | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2021-08-05 | — | — | US | disclosed |
| US-10975041-B2 | Method for producing 5, 5-disubstituted-4, 5-dihydroisoxazole | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2021-04-13 | — | — | US | disclosed |
| EP-3789382-A1 | PRODUCTION METHOD FOR 5,5-DI-SUBSTITUTED-4,5-DIHYDROISOXAZOLE | Kumiai Chemical Industry Co., Ltd. (JP) | 2021-03-10 | — | — | EP | disclosed |
| US-20210047280-A1 | NOVEL METHOD FOR PRODUCING 5, 5-DISUBSTITUTED-4, 5-DIHYDROISOXAZOLE | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2021-02-18 | — | — | US | disclosed |
| CN-112004805-A | Process for producing 5, 5-disubstituted-4, 5-dihydroisoxazoles | 组合化学工业株式会社 | 2020-11-27 | — | — | CN | disclosed |
| EP-3725782-A1 | NOVEL METHOD FOR PRODUCING 5,5-DISUBSTITUTED-4,5-DIHYDROISOXAZOLE | Kumiai Chemical Industry Co., Ltd. (JP) | 2020-10-21 | — | — | EP | disclosed |
| CN-111491926-A | Novel method for producing 5, 5-disubstituted-4, 5-dihydroisoxazoles | 组合化学工业株式会社 | 2020-08-04 | — | — | CN | disclosed |
| EP-0569409-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047280-A1 | NOVEL METHOD FOR PRODUCING 5, 5-DISUBSTITUTED-4, 5-DIHYDROISOXAZOLE | CYP3A5, CYP4X1, SQLE | PTGS1 1033/4885CA1 391/4885CA2 344/4885 |
| US-20210238150-A1 | PRODUCTION METHOD FOR 5,5-DI-SUBSTITUTED-4,5-DIHYDROISOXAZOLE | CYP3A5, CYP3A4, DHPS | PTGS1 758/4885CA1 698/4885CA2 631/4885 |
| US-11753384-B2 | Production method for 5,5-di-substituted-4,5-dihydroisoxazole | CYP3A5, CYP3A4, DHPS | PTGS1 758/4885CA1 698/4885CA2 631/4885 |
| US-10975041-B2 | Method for producing 5, 5-disubstituted-4, 5-dihydroisoxazole | CYP3A5, CYP4X1, SQLE | PTGS1 952/4885CA1 375/4885CA2 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.