SCHEMBL9511166

SCHEMBL9511166

NC(=O)N(CCc1ccc2ccccc2c1N)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCEH1 Q6PIU2 1/20 0.39
CYP1A1 P04798 1/20 0.37
CYP1B1 Q16678 1/20 0.37
TP53 P04637 1/20 0.37
MTNR1A P48039 1/20 0.37
CYP2C19 P33261 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
TDP1 Q9NUW8 2/20 0.36
MEN1 O00255 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GLA P06280 2/20 0.35
TSHR P16473 2/20 0.35
HTT P42858 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL789838 0.85 MTNR1A (0.52) TP53MTNR1ACYP1A2TDP1MEN1
SCHEMBL5997308 0.75 CYP1A2 (0.53) NCEH1CYP1A1CYP1B1CYP2C19CYP1A2
SCHEMBL27776801 0.73 NPC1 (0.47) TP53CYP2C19TDP1MEN1CYP3A4
SCHEMBL28342504 0.71 LMNA (0.44) NCEH1CYP1A1CYP1B1MTNR1ACYP2C19
SCHEMBL20563202 0.71 MTNR1A (0.54) NCEH1CYP1A1CYP1B1MTNR1A
SCHEMBL5188455 0.71 TDP1 (0.62) NCEH1CYP1A1CYP1B1CYP2C19CYP1A2
SCHEMBL6261729 0.71 TP53 (0.58) TP53CYP2C19MEN1CYP3A4CYP2C9
SCHEMBL27363240 0.71 MAOB (0.48) TP53CYP2C19CYP1A2CYP2D6TDP1
SCHEMBL9444059 0.71 SLC6A4 (0.49) NCEH1CYP2C19CYP2D6KDM4EMAPT
SCHEMBL9511619 0.70 CA12 (0.51) CYP2C19CYP1A2CYP2D6TDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0337948-B1 Disperse dyes CIBA GEIGY AG (CH) 1993-12-08 EP claimed
EP-0337948-B1 Disperse dyes CIBA GEIGY AG (CH) 1993-12-08 EP disclosed