Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26077232 | 0.84 | CNR2 (0.47) | PTGS2CYP3A4CNR2CNR1KDM4E | |
| SCHEMBL7634231 | 0.84 | TSHR (0.44) | PTGS2CYP3A4CNR2CNR1KDM4E | |
| SCHEMBL28599339 | 0.84 | CNR2 (0.39) | PTGS2CYP3A4CNR2CNR1KDM4E | |
| SCHEMBL3362484 | 0.84 | PTGS2 (0.62) | PTGS2CYP3A4CNR2CNR1LTA4H | |
| SCHEMBL67909 | 0.84 | PTGS2 (0.70) | PTGS2CYP3A4CNR2CNR1LTA4H | |
| SCHEMBL12430083 | 0.82 | CYP3A4 (0.40) | PTGS2CYP3A4CNR2CNR1ALDH1A1 | |
| SCHEMBL16952302 | 0.78 | CNR2 (0.37) | PTGS2CYP3A4CNR2CNR1KDM4E | |
| SCHEMBL16959521 | 0.78 | LTA4H (0.40) | PTGS2CYP3A4ALDH1A1LTA4HHCAR1 | |
| SCHEMBL2458065 | 0.78 | SMN1; SMN2 (0.38) | PTGS2CYP3A4ALDH1A1GPR84HCAR1 | |
| SCHEMBL5168458 | 0.77 | PTGS2 (0.56) | PTGS2CYP3A4CNR2CNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414686-B1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1993-09-22 | — | — | EP | disclosed |
| EP-0414686-A1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES. | LUCIEN LAB (FR) | 1991-03-06 | — | — | EP | disclosed |
| WO-1989004819-A1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1989-06-01 | — | — | WO | disclosed |