Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACR | P10323 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14825173 | 0.78 | POLB (0.56) | TSHRHTTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL9510816 | 0.77 | MAPT (0.63) | HTTALDH1A1ACRSMN1; SMN2MAPT | |
| SCHEMBL21348471 | 0.77 | SMN1; SMN2 (0.64) | ALDH1A1L3MBTL1ACRSMN1; SMN2MAPT | |
| SCHEMBL6633619 | 0.75 | POLB (0.58) | HTTPOLBALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL32060705 | 0.73 | NPC1 (0.69) | POLBL3MBTL1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL28153253 | 0.73 | GRM5 (0.68) | TSHRHTTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL10038817 | 0.73 | NPC1 (0.69) | POLBL3MBTL1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL755315 | 0.73 | — | — | |
| SCHEMBL31501093 | 0.73 | NPC1 (0.49) | POLBALDH1A1L3MBTL1ACRS1PR4 | |
| SCHEMBL9512456 | 0.73 | GAA (0.71) | HTTALDH1A1L3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371876-B1 | Isoxazoles and isoxazolines with an anticonvulsive activity, and pharmaceutical compositions containing them | NOVAPHARME (FR) | 1993-11-24 | — | — | EP | claimed |
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | claimed |
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | disclosed |