Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | PYGM | P11217 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31411873 | 0.84 | KDM4E (0.55) | KDM4EKMT2AHIF1AHTT | |
| SCHEMBL29348788 | 0.83 | NPC1 (0.53) | POLBSMN1; SMN2PYGMRAB9ANPC1 | |
| SCHEMBL31411958 | 0.82 | HSD17B10 (0.62) | POLBSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL21348471 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL31411928 | 0.79 | BCAT2 (0.51) | POLBSMN1; SMN2PYGMRAB9AALDH1A1 | |
| SCHEMBL21348470 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9AALDH1A1NPC1NFKB1 | |
| SCHEMBL21695728 | 0.78 | ALDH1A1 (0.55) | POLBSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL31411895 | 0.77 | NPC1 (0.61) | SMN1; SMN2RAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL3759873 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2PYGMRAB9AALDH1A1KDM4E | |
| SCHEMBL9512937 | 0.75 | TSHR (0.48) | POLBSMN1; SMN2ALDH1A1NPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160287549-A1 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | GENZYME CORPORATION | 2016-10-06 | — | — | US | claimed |
| EP-3071199-A2 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | Genzyme Corporation (US) | 2016-09-28 | — | — | EP | claimed |
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | claimed |
| WO-2015077535-A2 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | GENZYME CORPORATION (US) | 2015-05-28 | — | — | WO | claimed |
| EP-1419161-A1 | SUBSTITUTED-HETEROARYL-7-AZA 2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-05-19 | — | — | EP | claimed |
| WO-2003018585-A1 | SUBSTITUTED-HETEROARYL-7-AZA[2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-03-06 | — | — | WO | claimed |
| EP-0026873-B1 | ISOXAZOLECARBOXYLIC ACID ANILIDES, THEIR PREPARATION, FUNGICIDAL COMPOSITIONS AND PROCESS FOR COMBATING FUNGI | BASF Aktiengesellschaft (DE) | 1982-10-06 | — | — | EP | claimed |
| US-4328236-A | FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | claimed |
| WO-2019005563-A1 | METHODS RELATED TO ACTIVATION OF THE BONE MORPHOGENIC PROTEIN SIGNALING PATHWAY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2019-01-03 | — | — | WO | disclosed |
| US-20160287549-A1 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | GENZYME CORPORATION | 2016-10-06 | — | — | US | disclosed |
| EP-3071199-A2 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | Genzyme Corporation (US) | 2016-09-28 | — | — | EP | disclosed |
| US-20160052935-A1 | COMPOUNDS FOR USE IN SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY | THE UNIVERSITY OF MASSACHUSETTS | 2016-02-25 | — | — | US | disclosed |
| US-9212209-B2 | Screening methods for spinal muscular atrophy | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2015-12-15 | — | — | US | disclosed |
| WO-2015077535-A2 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | GENZYME CORPORATION (US) | 2015-05-28 | — | — | WO | disclosed |
| US-20140193906-A1 | SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY | THE UNIVERSITY OF MASSACHUSETTS | 2014-07-10 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| EP-0821960-B1 | Use of xanthine derivatives combined with a 5-substituted-isoxazole-4-carboxamide derivative and/or a 2-cyano-3-hydroxycrotonamide derivative for the modulation of apoptosis | HOECHST AG (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-4328236-A | FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | disclosed |
| US-4328236-A | FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | disclosed |
| US-4328236-A | FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052935-A1 | COMPOUNDS FOR USE IN SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY | SMN1; SMN2, CPT1B, MTPN | POLB 454/4885SMN1; SMN2 1/4885PYGM 7/4885 |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | POLB 1539/4885SMN1; SMN2 2426/4885PYGM 4210/4885 |
| US-20160287549-A1 | NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES | DHODH, DLD, HAGH | POLB 1651/4885SMN1; SMN2 25/4885PYGM 3318/4885 |
| US-20140193906-A1 | SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY | SMN1; SMN2, MYOF, MTPN | POLB 438/4885SMN1; SMN2 1/4885PYGM 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.