Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 14/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661481 | 0.80 | GPBAR1 (0.40) | HSD17B1GPBAR1 | |
| SCHEMBL9510820 | 0.79 | HSD17B1 (0.51) | HSD17B1GPBAR1HSD17B2ALDH1A1STS | |
| SCHEMBL2362735 | 0.75 | CHRNA4 (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9133802 | 0.74 | HSD17B1 (0.47) | HSD17B1GPBAR1HSD17B2ALDH1A1STS | |
| SCHEMBL9136309 | 0.73 | HSD17B1 (0.46) | HSD17B1GPBAR1HSD17B2ALDH1A1TP53 | |
| SCHEMBL3807892 | 0.72 | ALDH1A1 (0.51) | HSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL20041120 | 0.72 | ALDH1A1 (0.59) | HSD17B1HSD17B2ALDH1A1TP53MAPT | |
| SCHEMBL9512980 | 0.72 | HSD17B1 (0.52) | HSD17B1GPBAR1HSD17B2ALDH1A1TP53 | |
| SCHEMBL9134167 | 0.72 | HSD17B1 (0.47) | HSD17B1GPBAR1HSD17B2 | |
| SCHEMBL9133135 | 0.71 | HSD17B1 (0.46) | HSD17B1HSD17B2ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371876-B1 | Isoxazoles and isoxazolines with an anticonvulsive activity, and pharmaceutical compositions containing them | NOVAPHARME (FR) | 1993-11-24 | — | — | EP | claimed |
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | claimed |
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | disclosed |