Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512940 | 0.80 | HSD17B1 (0.51) | GPBAR1HSD17B1 | |
| SCHEMBL2088432 | 0.73 | POLQ (0.50) | GPBAR1POLQHDAC6 | |
| SCHEMBL25076165 | 0.73 | TSPO (0.47) | GPBAR1POLQHDAC6 | |
| SCHEMBL2088431 | 0.73 | POLQ (0.46) | GPBAR1POLQHDAC6 | |
| SCHEMBL4602848 | 0.71 | POLQ (0.45) | GPBAR1POLQHDAC6RAB9A | |
| SCHEMBL5476758 | 0.71 | POLQ (0.45) | GPBAR1POLQHDAC6 | |
| SCHEMBL7366943 | 0.70 | GPBAR1 (0.44) | GPBAR1POLQHDAC6 | |
| SCHEMBL2362735 | 0.70 | CHRNA4 (0.39) | HDAC4RAPGEF3RAPGEF4RAB9A | |
| SCHEMBL31222332 | 0.70 | TACR1 (0.46) | GPBAR1POLQHDAC6 | |
| SCHEMBL353627 | 0.70 | S1PR4 (0.35) | HTTRAPGEF3RAPGEF4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488028-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |
| EP-2013212-A1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AS INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1784386-A4 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO INC (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1855685-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2007127138-A1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AS INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| EP-1784386-A2 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006078598-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-07-27 | — | — | WO | disclosed |
| WO-2006017215-A2 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-02-16 | — | — | WO | disclosed |