Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9512922 | 0.99 | THRB (0.57) | THRBHTR2AP2RX7LMNATDP1 | |
| SCHEMBL9321162 | 0.90 | THRB (0.54) | THRBHTR2AP2RX7LMNATDP1 | |
| SCHEMBL9425985 | 0.87 | THRB (0.51) | THRBHTR2AP2RX7LMNATDP1 | |
| SCHEMBL9512996 | 0.87 | THRB (0.65) | THRBHTR2ALMNATDP1MEN1 | |
| SCHEMBL9426474 | 0.86 | KCNJ1 (0.57) | THRBHTR2ALMNAKCNH2POLB | |
| Hydrochloric Acid SCHEMBL10564268 | 0.86 | THRB (0.63) | THRBHTR2ALMNATDP1MEN1 | |
| SCHEMBL9426050 | 0.85 | HTR2A (0.49) | THRBHTR2AP2RX7LMNAKMT2A | |
| SCHEMBL9425944 | 0.84 | HTR2A (0.48) | THRBHTR2AP2RX7LMNATDP1 | |
| SCHEMBL9321227 | 0.84 | POLB (0.49) | THRBHTR2ALMNATDP1KMT2A | |
| Hydrochloric Acid SCHEMBL9426244 | 0.84 | AVPR2 (0.52) | THRBHTR2AP2RX7LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |