Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426050 | 0.89 | HTR2A (0.49) | THRBHTR2ALMNAPOLBGAA | |
| Hydrochloric Acid SCHEMBL9426244 | 0.88 | AVPR2 (0.52) | THRBHTR2AAVPR2LMNAPOLB | |
| SCHEMBL9426845 | 0.87 | CYP2D6 (0.50) | THRBHTR2ALMNAPOLBGAA | |
| SCHEMBL9513197 | 0.87 | THRB (0.58) | THRBHTR2ALMNAPOLBGAA | |
| SCHEMBL9321227 | 0.86 | POLB (0.49) | THRBHTR2ALMNAPOLBMAPK1 | |
| Hydrochloric Acid SCHEMBL9512922 | 0.86 | THRB (0.57) | THRBHTR2ALMNAPOLBGAA | |
| SCHEMBL9426465 | 0.86 | HPGD (0.52) | THRBHTR2ALMNAPOLBGAA | |
| SCHEMBL9320604 | 0.84 | THRB (0.68) | THRBHTR2ALMNAPOLBMEN1 | |
| SCHEMBL9321162 | 0.83 | THRB (0.54) | THRBHTR2ALMNAPOLBGAA | |
| Hydrochloric Acid SCHEMBL9426784 | 0.83 | THRB (0.67) | THRBHTR2ALMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321027-A | Analgesic | CIBA-GEIGY CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |
| EP-0489690-A1 | Substituted N-Benzoyl-N'-(2-phenylethyl)-piperazines | CIBA-GEIGY AG (CH) | 1992-06-10 | — | — | EP | disclosed |