Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9513006 | 0.99 | LMNA (0.78) | LMNAMEN1KMT2ATHRBKCNH2 | |
| SCHEMBL9513169 | 0.89 | LMNA (0.65) | LMNAMEN1KMT2ATHRBKCNH2 | |
| SCHEMBL9515612 | 0.88 | THRB (0.68) | LMNAMEN1KMT2ATHRBKCNH2 | |
| Hydrochloric Acid SCHEMBL9512934 | 0.88 | LMNA (0.64) | LMNAMEN1KMT2ATHRBKCNH2 | |
| Hydrochloric Acid SCHEMBL9516717 | 0.87 | THRB (0.67) | LMNAMEN1KMT2ATHRBKCNH2 | |
| SCHEMBL9513241 | 0.86 | THRB (0.82) | LMNAMEN1KMT2ATHRBKCNH2 | |
| SCHEMBL9514284 | 0.86 | LMNA (0.61) | LMNAMEN1KMT2ATHRBKCNH2 | |
| SCHEMBL9513026 | 0.86 | WNK1 (0.64) | LMNAMEN1KMT2ATHRBKDM4E | |
| SCHEMBL9513036 | 0.86 | LMNA (0.61) | LMNAMEN1KMT2ATHRBKCNH2 | |
| Hydrochloric Acid SCHEMBL9513192 | 0.85 | WNK1 (0.63) | LMNAMEN1KMT2ATHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |