Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.47 |
| ▸ | CA2 | P00918 | 18/20 | 0.47 |
| ▸ | CA9 | Q16790 | 8/20 | 0.47 |
| ▸ | CA12 | O43570 | 7/20 | 0.47 |
| ▸ | CA3 | P07451 | 7/20 | 0.47 |
| ▸ | CA4 | P22748 | 7/20 | 0.47 |
| ▸ | CA6 | P23280 | 7/20 | 0.47 |
| ▸ | CA5A | P35218 | 7/20 | 0.47 |
| ▸ | CA7 | P43166 | 7/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 7/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 6/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516814 | 0.75 | CA2 (0.51) | CA1CA2CA9CA12CA3 | |
| SCHEMBL11069560 | 0.72 | ALDH1A1 (0.44) | — | |
| SCHEMBL9701011 | 0.72 | CA2 (0.51) | CA1CA2CA9CA12CA3 | |
| SCHEMBL7595797 | 0.72 | INPPL1 (0.34) | CA1CA2CA9CA12CA4 | |
| SCHEMBL10757156 | 0.71 | IDO1 (0.46) | CA1CA2CA9CA12CA4 | |
| SCHEMBL6932679 | 0.70 | GAA (0.33) | CA1CA2CA4SMN1; SMN2 | |
| Sulfamate SCHEMBL9451534 | 0.70 | TP53 (0.52) | SMN1; SMN2 | |
| SCHEMBL5014186 | 0.70 | CA1 (0.70) | CA1CA2CA9CA12CA3 | |
| SCHEMBL6932671 | 0.69 | DUSP5 (0.39) | SMN1; SMN2 | |
| SCHEMBL941210 | 0.69 | MMP2 (0.55) | CA1CA2CA9CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539527-A1 | ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5157044-A | Treating glaucoma | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-10-20 | — | — | US | disclosed |
| US-5095026-A | PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-03-10 | — | — | US | disclosed |
| WO-1992000287-A2 | ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-01-09 | — | — | WO | disclosed |