Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.35 |
| ▸ | FDPS | P14324 | 9/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514697 | 0.80 | LPAR1 (0.46) | LPAR1LPAR3GGPS1FDPS | |
| SCHEMBL8743575 | 0.72 | LPAR1 (0.59) | LPAR1LPAR3GGPS1FDPS | |
| SCHEMBL15110889 | 0.68 | LPAR1 (0.45) | LPAR1LPAR3CYP4F2CYP4A11GGPS1 | |
| 1,6-Hexanediol SCHEMBL27918595 | 0.68 | LMNA (0.50) | LPAR3LMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL193245 | 0.67 | LPAR1 (1.00) | LPAR1LPAR3GGPS1FDPSCES2 | |
| SCHEMBL8198866 | 0.66 | CYP4F2 (0.42) | LPAR1LPAR3CYP4F2CYP4A11LMNA | |
| SCHEMBL14214460 | 0.66 | LMNA (0.48) | LPAR1LPAR3CYP4F2CYP4A11LMNA | |
| SCHEMBL23015199 | 0.66 | LMNA (0.62) | LPAR1LPAR3LMNAALDH1A1HSD17B10 | |
| SCHEMBL17830599 | 0.66 | LMNA (0.62) | LPAR1LPAR3LMNAALDH1A1HSD17B10 | |
| SCHEMBL20654770 | 0.66 | CYP4F2 (0.34) | LPAR1LPAR3CYP4F2CYP4A11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338887-B1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMA (US) | 1993-12-08 | — | — | EP | disclosed |
| US-4988680-A | Phosphorylase inhibitors, immuno suppressants, parasiticides, antileukemia agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0338168-A1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-25 | — | — | EP | disclosed |
| EP-0338887-A1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-25 | — | — | EP | disclosed |