Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 7/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580775 | 0.86 | SPHK1 (0.55) | KMT2ASPHK1MEN1IGF1RADRB2 | |
| SCHEMBL9513530 | 0.84 | KMT2A (0.58) | KMT2ASPHK1MEN1IGF1RADRB2 | |
| SCHEMBL9515064 | 0.81 | IGF1R (0.74) | KMT2ASPHK1MEN1IGF1RHTR1A | |
| SCHEMBL6375438 | 0.81 | SPHK1 (0.60) | KMT2ASPHK1MEN1IGF1RADRB2 | |
| SCHEMBL10680303 | 0.81 | CA2 (0.66) | CA1CA2CA12CA9CA7 | |
| SCHEMBL10578945 | 0.80 | SPHK1 (0.62) | KMT2ASPHK1MEN1IGF1RADRB2 | |
| SCHEMBL10580782 | 0.78 | SPHK1 (0.57) | KMT2ASPHK1MEN1IGF1RADRB2 | |
| SCHEMBL9513528 | 0.78 | CA1 (0.54) | CA1CA2CA12CA9CA7 | |
| SCHEMBL9515031 | 0.77 | HTR1A (0.53) | CA1CA2CA12CA9HTR1A | |
| SCHEMBL11721357 | 0.76 | GAA (0.56) | KMT2ASPHK1MEN1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |