Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934656 | 0.86 | CTSA (0.44) | CTSAKDM4E | |
| SCHEMBL4040384 | 0.84 | EIF4E (0.46) | HSD17B14MCL1DHODHEIF4EKMT2A | |
| SCHEMBL1050097 | 0.74 | EIF4E (0.44) | HSD17B14MCL1DHODHEIF4ES1PR1 | |
| SCHEMBL934784 | 0.74 | EIF4E (0.44) | HSD17B14MCL1DHODHEIF4EKMT2A | |
| SCHEMBL545109 | 0.72 | HSD17B14 (0.40) | HSD17B14MCL1EIF4ECTSAALDH1A1 | |
| SCHEMBL951351 | 0.71 | KDM4E (0.43) | CTSAALDH1A1KDM4ERAB9AKMO | |
| SCHEMBL4037851 | 0.70 | PTGER1 (0.47) | MCL1DHODHEIF4ECTSA | |
| SCHEMBL28291361 | 0.69 | MGAM (0.43) | MCL1EIF4EALDH1A1ACMSDKDM4E | |
| SCHEMBL912838 | 0.68 | KDM4E (0.45) | EIF4EKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL2772848 | 0.66 | S1PR1 (0.69) | S1PR1S1PR3MAPTNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011007091-A1 | DERIVATIVES OF 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS UROTENSIN-II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2011-01-20 | — | — | WO | disclosed |