Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 18/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951541 | 0.86 | HSD17B14 (0.43) | CTSAKDM4E | |
| SCHEMBL951351 | 0.83 | KDM4E (0.43) | CTSAKDM4EL3MBTL1ECE1 | |
| SCHEMBL4040384 | 0.74 | EIF4E (0.46) | — | |
| SCHEMBL4037851 | 0.74 | PTGER1 (0.47) | CTSA | |
| SCHEMBL2491639 | 0.74 | MCL1 (0.43) | KDM4E | |
| SCHEMBL991632 | 0.73 | MRGPRX4 (0.43) | CTSA | |
| SCHEMBL1050097 | 0.72 | EIF4E (0.44) | — | |
| SCHEMBL934784 | 0.72 | EIF4E (0.44) | — | |
| SCHEMBL912838 | 0.71 | KDM4E (0.45) | KDM4E | |
| SCHEMBL4043788 | 0.70 | MRGPRX4 (0.43) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011007091-A1 | DERIVATIVES OF 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS UROTENSIN-II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2011-01-20 | — | — | WO | disclosed |